Human iPS Cells in Disease Modelling by Keiichi Fukuda

Human iPS Cells in Disease Modelling



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Human iPS Cells in Disease Modelling Keiichi Fukuda ebook
ISBN: 9784431559641
Page: 99
Format: pdf
Publisher: Springer Japan


Human iPS cells have a great potential to be cell sources for regenerative medicine because of the promise of infinite self-renewal and the capability to. Using human induced pluripotent stem cells to model cerebellar disease: Hope and hype. Modeling Familial Cancer with Induced Pluripotent Stem Cells .. The establishment of human induced pluripotent stem cells (hiPSCs) has led to a variety of new disease models. Embryonic and induced pluripotent stem cells as a model for liver disease. Wolfram syndrome is a rare autosomal recessive genetic disorder with clinical signs apparent in early childhood. Keywords: .drug screening; human embryonic stem cells; monogenic diseases;human induced pluripotent stem cells; pathological modelling. Keywords: Induced pluripotent stem cells, liver diseases, hepatocyte differentiation, . Modeling human diseases “in a dish” is firmly rooted in human embryonic stemcell (hESC) biology. IPS cell-based disease modeling. IPSCs were derived from a mouse model of human sickle cell anaemia. Previously available human drug screening models relied on the patient's samples or immortalized, tumor-derived cell lines. Cells promised to pro- vide invaluable models of human disease for. That must be overcome before iPS cell therapies will be available in clinics. We are using induced pluripotent stem cell ( iPSC) lines to study disease mechanisms in human cells by reverse genetics. Human induced pluripotent stem cells and neurodegenerative disease: and allow in-vitro disease modeling, drug screening, and cell replacement therapy. For the vast majority of kidney diseases, there are no specific human diseasemodels available, and no specific treatments or biomarkers.





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